CYP4Fサブファミリー(ロイコトリエンB_4ω水酸化酵素)

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概要

• 論文の詳細を見る

• Leukotriene B_4 ω-hydroxylation was reported in 1981 immediately after discovery of leukotriene B_4. After that, a large number of investigations about leukotriene B_4 ω-hydroxylase in neutrophils and liver have been presented. The primary structures of the enzymes were clarified by cDNA cloning, and they were found to be novel P450s which belong to the CYP4F subfamily. At present, seventeen members of this subfamily have been discovered by cDNA cloning and by genome projects. Most of them show leukotriene B_4 ω-hydroxylase activity, and catalyze hydroxylation of various substrates including lipoxygenase dependent arachidonate metabolites, prostaglandins, and drugs. They also distribute a variety of tissues such as leukocyte, liver, kidney, seminal vesicles, and brain. Now, CYP4F enzymes are thought to have various functions.

• 福山大学の論文

著者

• 菊田 安至

  福山大学生命工学部

• 菊田 安至

  福山大学工学部食品工学科

関連論文

• ω-ヒドロキシ脂肪酸の定量分析
• ヒト腎ミクロゾームの脂肪酸ω水酸化酵素のクローニング及び同酵素と高血圧発症との関係について
• ロイコトリエンB_4ω水酸化酵素の研究
• CYP4Fサブファミリー(ロイコトリエンB_4ω水酸化酵素)

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