癌浸潤及び放射線治療による下顎骨Ca, Pイオン動態について
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概要
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Many observations have been roentgenologically and histopathologically made on the extensive area of oral malignant tumor involving the mandible. In order to analyze much more exactly to the extension of carcinoma involving the mandible, the author studied the dynamics of inorganic ions in the mandibular bones and tried to apply the clinic. Using the techniques of electron probe microanalyzer and contact microradiography, Ca and P ions were examined in the mandibular bones extirpated from the cases of carcinoma, arising in the mandibular gingivas, the tongues and the salivary glands. Simultaneously, after electron irradiation to the mandibular bones of rabbits, its influences were investigated. The following results were obtained. 1) Ca ion was gradually reducing in the mandible with tumoral invasion, especially most remarkable in the bone contacted the tumor. It appeared to start the reduction in the bone, into which tumors did not invade yet and were apart from tumor. On the other hand, P ion did not show the similar tendency as that of Ca ion. 2) Irradiation gave the influence to Ca ion in the mandibular bones as well as that of tumoral invasion, the higher dosis of irradiation used. However, the influence to P ion was not observed. 3) Its influence to Ca ion showed the minimal value one week after irradiation and irreversible four weeks, without dependence on the dosis of irradiation. 4) On the contact microradiogram, bizarre resorption in the surrounding bones with progressive invasion were frequently observed and the highly calcified layer in the inner wall of Haversian canal extensively disappeared. These findings could be observed during one to four weeks after irradiation. 5) Electron probe microanalyzer was probed to be able to handle easier and to be the most ideal analyzer for examining the inorganic ions in the materials of hard tissues without destrution of tissues.
- 神戸大学の論文