糖尿病における膵内外分泌機能相関に関する研究

概要

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Relationship between exocrine and endocrine pancreatic function was investigated in 110 patients with diabetes mellitus. Exocrine pancreatic functions were evaluated .by the determination of serum pancreatic isoamylase activity and exocrine pancreatic secretory response to intravenous injection of pancreozymin (1U/kg) and secretin (1U/kg) (P-S test). Endocrine pancreatic function was estimated by the IRI or CPR response to oral glucose load (50g). Serum pancreatic isoamylase activity in diabetics was significantly lower than than that in normal subjects, and inversely related to the fasting blood glucose concentration. Pancreatic amylase output in response to pancreozymin and IRI response to glucose load were significantly lower in diabetics with serum pancreatic isoamylase activity less than 50% of total activity than in diabetics with normal pancreatic isoamylase activity (≧50% of total activity). Exocrine pancreatic functions in diabetics showing IRI or CPR response to glucose load were similar to those in normal subjects, whereas diabetics with no detectable increase in IRI or CPR response had significantly decreased serum pancreatic isoamylase activity, and decreased amylase output and maximal bicarbonate concentration in P-S test. These results suggest that exocrine pancreatic dysfunction in diabetics is probably due to the lack of endogenous insulin secretion.
神戸大学の論文