グルカゴン、インスリンに対する結合抗体を有する症例の検索とその病態特性

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The purpose of the present study is to clarify the prevalence and clinical characteristics of patients who have glucagon-or insulin-binding antibody. From a random examination for 4,800 patients with various diseases and 443 patients with thyroid disease, following results were obtained. 1. Glucagon-binding sera were found in 7 patients ; 3(0.063%)had specific antibody to glucagon, while 4 had non-specific binding serum. Clinical diagnosis of 3 patients with specific antibody was chronic hepatitis, bronchial asthma and ileus, while that of the other 4 with non-specific binding serum was sepsis, spinalioma, rectum cancer and grave neonatal icterus, respectively. Immunoglobulin class of glucagon-specific antibody was determined in 2 out of 3 patients by immunological and biochemical method and IgG was demonstrated. However, light chain type was not determined. These results suggest that the glucagon-specific antibody in 3 patients may occur due to glucagon autoimmunity induced by immunological abnormalities under various derangement of immune system. 2. Insulin- and glucagon-binding antibodies were investigated in 283 patients with hyperthyroidism treated with methimazole or propylthiouracil, 100 patients with no therapy and 60 patients with chronic thyroiditis. Insulin-binding antibody was found in 6 patients (1.4 %) with hyperthyroidism under methimazole treatment, but glucagon-binding antibody was not demonstrated in any patients. Immunoglobulin class of insulin binding antibody in 3 out of 6 patients with hyperthyroidism was IgG. Light chain type in 1 of 3 was λ. These results may suggest that methimazole has some influence on the production of autoantibody to endogenous insulin in hyperthyroidism.
神戸大学の論文

グルカゴン、インスリンに対する結合抗体を有する症例の検索とその病態特性

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