胃嚢移植法による胃酸分泌機序の研究

概要

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In order to clarify the nervous control of the gastric secretion, the completely denervated stomach was prepared upon which the mode of gastric secretion was studied. In dogs, Heidenhain's gastric pouch was first prepared which was then converted to Gregory's pouch. Finally the autotransplantation of the freed gastric pouch to the neck was accomplished by dividing the splenic vessels and anastomosing them with the cervical vessels by use of the small vessel anastomosing instrument. The secretion of the free acid from these different types of gastric pouches was comparatively analyzed by means of 24 hour secretion, food stimulation, gastrin stimulation and of histamine stimulation. The amount of secretion increased by 12% when the Heidenhain's pouch was converted to the Gregory's pouch, and it further increased by 25% when the latter was completely denervated by being transplanted to the neck. However, no significant differences were observed following the Histamine stimulation. When both the autoand homotransplantations of the gastric pouches were performed in the same dog, the amount of gastric secretion from these pouches were about the same.
千葉大学の論文