腸の良性および悪性腫瘍における基質に関する病理組織学的ならびに電子顕微鏡的研究
スポンサーリンク
概要
- 論文の詳細を見る
Histopathological and electron microscopic studies for stromal changes in the epithelial benign and malignant tumors of the intestine were performed in order to detect the finding of "destructive and infiltrative growth" specific for cancer cells. The materials were examined light microscopically on autopsy specimens of 27 cases of simple proliferative polyp, 3 cases of atypical proliferative polyp and of 14 intestinal carcinoma, while on 8 surgical materials including 1 case of simple proliferative polyposis, 1 case of atypical proliferative polyposis and 6 cases of carcinoma of the large intestine were examined light microscopically. The observations obtained were as following: 1) Light microscopically, the degenerative changes in mesenchymal cells of the stroma closely adjacent to their glandular epithelial cells were scarcely observed in simple proliferative polyps, while the mesenchymal cells in atypical proliferative polyps showed partially degenerative changes, and colloidal sudan gave definite granules of fatty degeneration. In carcinoma of the intestine, mesenchymodystrophy and mesenchymolysis (TAKIZAWA, 1962) of the mesenchymal tissue were clearly found. These changes included the mesenchymal cells and also fine fibrils of the stroma closely adjacent to their parenchymatous cells of carcinoma indicate the changes of their fatty degeneration, disintegration, fusion and disappearance etc. The finding of the progressive vacuolar degeneration in the carcinoma cells were strikingly observed. 2) Electron microscopically, in a simple proliferative polyposis of the large intestine the degenerative changes in mesenchymal cells of the stroma closely adjacent to its glandular epithelial cells were scarcely found. On the contrary, in a atypical proliferative polyposis a little cytoplasmic projection of its atypical epithelial cell which is presumed protruding into the stroma through its basement membrane was found slightly and scatterly, adhering to a mesenchymal cell which implies the regressive change by increasing in electron density. Besides, in carcinoma of the large intestine numerous cytoplasmic projections of their parenchymatous cells protruding continuously into the stroma through the focal defects of its basement membrane were observed as progressive vacuolar degeneration, with the observations of mesenchymodystrophy and mesenchy molysis in microscopic findings. Accordingly, it will be considered that mesenchymodystrophy, mesenchymolysis in the stromal connective tissuse of carcinoma and progressive vacuolar degeneration in parenchymatous cells of carcinoma indicate morphological features closely related to the process of malignant change in the intestine.
- 千葉大学の論文
著者
関連論文
- 36. 十二指腸潰瘍に対する迷走神経切離幽門成形術100例の経験について(第519回千葉医学会例会 第8回佐藤外科例会)
- 64. 硬性癌として全摘手術を施行した胃サルコイドの一例について(第510回千葉医学会例会 第7回佐藤外科例会)
- 70. 最近1年間における肝内胆管結石症5例について(第510回千葉医学会例会 第7回佐藤外科例会)
- 52. 胃切除後有愁訴例の内視鏡的検討(第519回千葉医学会例会 第8回佐藤外科例会)
- 9. 小児胃癌の一例(第6回佐藤外科例会,第501回千葉医学会例会)
- 51.腹部外科手術後の肝機能障害に関する検討 : トランスアミナーゼ,ビリルビンを中心に(第730回 千葉医学会例会・第1回 磯野外科例会)
- 38.食道胃接合部の扁平上皮癌と胃体部の多発性腺癌の合併した1例(第665回 千葉医学会例会・第18回 佐藤外科例会)
- 29.著明な脾臓浸潤を呈した胃悪性リンパ腫の1治験例(第646回千葉医学会例会・第17回佐藤外科例会)
- 腸の良性および悪性腫瘍における基質に関する病理組織学的ならびに電子顕微鏡的研究
- 27. 腸の良性および悪性腫瘍における基質に関する病理組織学的ならびに電子顕微鏡的研究(第473回千葉医学会例会,第4回佐藤外科例会)
- 12. 腸の良性および蕃性腫瘍における基質に関する研究(第11報)(第452回千葉医学会例会 第3回佐藤外科例会)
- 21. 腸の良性および悪性腫瘍における基質に関する研究(第445回千葉医学会例会 第2回佐藤外科例会)
- 3.胃肉腫を疑わしめた穿孔性胃潰瘍癌の1治験例(第431回千葉医学会例会,第1回佐藤外科例会)