The effect of glutathione on the rabbit ERG Its statistical observation (Symposium on electroretinography〔議事録〕)

概要

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Using mature albino rabbits weighing approximately 2 kg, the effect of glutathione (50 mg/kg) on the ERG was studied under the scotopic condition and the following results were obtained. Concerning changes in amplitudes of the c-waves, the "t" test showed no significant difference at the 1 per cent. level between the series. However, the high significant difference was revealed in changes in amplitudes of the a-waves in 5 to 20 minutes and in amplitudes of the b-waves in 10 to 25 minutes after intravenous injection. As the result, it might be possible to presume that glutathione would participate in the earlier stage of the retinal metabolism as a co-factor in the electron transfer system to activate the revolution of TCA cycles and facilitate the action of oxidereduction system causing the elevation of the energy level in the living organism or specifically the retina and subsequent increase of the amplitudes.
千葉大学の論文