On Serum Lipids in Various Hepatic Diseases : Changes in fatty acid composition of cholesterol esters
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概要
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Factors that might affect the fatty acid composition of serum cholesterol esters (Ch.E.) in human beings have been studied by many researchers. Age (1, 2, 3) and dietary conditions (4, 5) have been known to show some effects on the fatty acid composition of serum Ch.E. Studies have also been reported on the fatty acid composition of serum Ch.E. in patients with various diseases, such as diabetes mellitus (6, 7), atherosclerosis (2, 3, 7), idiopathic hypercholesterolemia (3) and nephrosis (7). It has been shown in these diseases that saturated and monounsaturated fatty acids are increased and polyunsaturated fatty acids are decreased in serum Ch.E. composition. High levels of serum total cholesterol (T.Ch.) were observed in these diseases, and the relationships between the fatty acid composition of Ch.E. and the level of T.Ch. in serum were discussed by Goodman (8). In hepatic parenchymal diseases, the levels of serum T.Ch. were known to have a tendency to decrease (9), but the changes in fatty acid composition of serum Ch.E. were similar to those of hypercholesterolemic diseases (10, 11, 12, 13). Although the mechanismus of these changes were yet obscure, it is probable that the disturbances of the fatty acid and Ch.E. metabolism are concerned with these changes of fatty acid composition of serum Ch.E. in hepatic diseases. The studies described in this paper were undertaken to observe the changes in fatty acid composition of serum Ch.E. in hepatic diseases in detail, and further to investigate certain aspects of serum Ch.E. metabolism in these pathological conditions.
- 千葉大学の論文