薬剤-宿主-寄生体の関係よりみた実験連鎖球菌症の化学療法の検討
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概要
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The efficacy of the various antibiotics against the muscle abscess of mice that were induced by the injection of hemolytic streptococcus was investigated in the case of treatment of PC, TC and EM, and combined treatment of protein-lysis enzyme or glucocorticoid from the results of the number of bacteria in the abscess and the histological findings. The treatment of abscess induced by streptococcus and staphylococcus or E. coli were also examined using various antibiotics. PC reduced most remarkably the number of bacteria of the abscess and produced well localized abscess in the long period treatment, although it did not reduced the size of the swelling of the abscess in 3 days treatment. On the other hand, TC reduced the size of the swelling within 3 days treatment, but it could not eradicate the organisms from the abscess completely. The efficacy of the EM was inferior to the effects of the above both drugs. In the PC treatment combined with glucocorticoid, the abscess had relatively thin capsul isolated from the normal muscle tissue. In the treatment combined with proteinlysis enzyme, on the contrary, it had thick one. There were no difference in the effects reducing the number of organisms in the abscess in both treatment groups. When streptococci were infected into the muscle with staphylococci of coli bacilli, the abscess developed much more strikingly. Also PC was the best effective drug from the treatment of these abscesses. TC, CP and EM were not effective significantly.
- 千葉大学の論文