Application of in vivo methodologies to investigation of biological structure, function and xenobiotic response in see-through medaka (Oryzias latipes)

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We describe here the development and application of non invasive in vivo methodologies to the investigation of biological structure, function and xenobiotic response in see-through medaka (STII; Oryzias latipes). In vivo studies in STII medaka provided novel insights into hepatobiliary architecture, development and toxic response, in both 2 and 3 dimensions. As the presented findings suggest, STII medaka provide a unique means for high resolution in vivo study, and the future opportunity to integrate mechanisms of toxicity (e.g. genomic, proteomic information) with phenotypic changes at the system level (the overarching goal of our laboratory). While our focus has been the hepatobiliary system, other organ systems are equally amenable to in vivo study, and we consider the potential for discovery, within the context of in vivo investigation in STII medaka, as significant.
名古屋大学の論文