壁内神経叢変性腸管の実験的作成ならびにその病態生理について

概要

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There are esophageal achalasia, congenital pylorus stenosis and Hirschsprung's disease with the general acceptance that the pathogenesis is due to absence or degeneration of Auerbach's plexus. This report purports to describe the experimental selective destruction of Auerbach's plexus in intestinal wall and confirm the pathogenesis. Mongrel adult dogs were utilized, whose distal portion of ileum was per fused with Tyrode's solution containing sublimate after clipping blood vessels. One month later, electromyograms were taken, the per fused portion was resected and pathological changes wese investigated with silver and cholinesterase staining. 1. In ganglion cells in Auerbach's plexus of the per fused intestinal portion, degenerative changes were observed such as deviation, extruding or vacuolization of nuclei, and atrophy or vacuolization of cytoplasm, and disintegration, vacuolization, swelling and granulating of nerve fibers. 2. Gholinesterase activity in Auerbach's plexus was diminished in the per fused portion of intestine. 3. X-ray examination showed stenotic finding as narrow segment without organic changes in intestinal wall. 4. On the electromyogram of intestine slight decrease of electric activity and tendency of irregularity were demonstrated. Per fused portion reacted more sensitively than normal segment to vagostigmine administration.
千葉大学の論文