放射性リン(P^<32>)投与による中枢神経系の形態ならびに組織発生学的研究(<特集>脳と神経の研究III)

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概要

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• Amphibian larvae (Bufo vulgaris formosus) in which histogenesis and growth of the central nervous system (CNS) were proceeding were bred in water containing 2.5 μC/cc of P^<32> for 5 days, followed by P^<32> free water for 38 days to study the influence of P^<32> on the developing CNS. The control and P^<32> administered larvae were microscopically observed. In the early tadpole stage, the nervous tissue consisted mainly of the germinal and migrated cell layers. The cells of these layers had a single ovoid nucleus, with the cytoplasm in small amount. The undifferentiated cell layer was located lateral to the migrated cell layer, and composed of cells with a rounded nucleus and rather scanty cytoplasm. That layer and white matter were undergrown. The migrated cell layer was the most radiosensitve to P^<32> radiation and showed degenerative changes. These changes were apparent in the telencephalon, the dorsal region of the diencephalon and the mesencephalon, the cranial part of the rhombencephalon, the medulla oblongata and the spinal cord. Nine days after administration of P^<32>, the migrated cell layer began to undergo gradual disappearance and mitoses in the germinal layer decreased in number progressively ; therefore, the growth of the CNS was inhibited and its size CNS was small. These changes were especially prominent in the dorsal region of the mesencephalon and the cranial part of the rhombencephalon. After 36 days, mitoses were repeated in the germinal layer and active proliferation of cells was observed in the migrated cell layer. The disturbance of the morphogenetic process in the CNS was ascribed to the inhibition of the histogenetic process of the CNS.

• 千葉大学の論文
• 1966-11-28

著者

• 白井 敏雄

  千大 3解剖

• 白井 敏雄

  千葉大学医学部第三解剖学教室

関連論文

• 1)放射性リン(P^)の中枢神経系の形態ならびに組織発生に及ぼす影響(脳と神経,シンポジウム,第43回千葉医学会総会,第12回千葉県医師会学術大会連合大会,第5回日医医学講座)
• 放射性リン(P^)投与による中枢神経系の形態ならびに組織発生学的研究(脳と神経の研究III)

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