慢性肝炎の前硬変期における臨床病理学的研究
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概要
- 論文の詳細を見る
I studied the histologic findings, liver function tests and clinical histories of 52 cases of precirrhosis and 51 of chronic hepatitis, and obtained the following results. i) I defined a word "precirrhosis" as follows. That is, precirrhosis is the progressed form of chronic hepatitis and of having pseudolobule in part and not diffusely. The cases of precirrhosis differed from the cases of chronic hepatitis not only histologically but also functionally. Therefore, I felt that precirrhosis occupied an important part of chronic hepatitis both clinically and pathologically. ii) I divided cases of precirrhosis into two groups by their clinical histories, and studied the difference between them. A-group consisted of cases of drunkard and cases with metabolic disease. V-group consisted of all cases other than A-group, for instance, cases with viral hepatitis on their clinical histories and cases with no special histories. Histologically, V-group showed many times predominant cellular infiltration in the portal triads and in peripheral zones of the lobule, therefore, the border between stroma and parenchyma was not distinct. Collagenisation of the connective tissue fibers was poor in inflammatory portions in the portal triads. Kupffer cell proliferation was often found. On the other hand, in A-group cellular infiltration in the portal triads was relatively poor, and the border between stroma and parenchyma was generally distinct. Collagenisation of the connective tissue fibers was rich in almost cases. Kupffer cell proliferation was poor. On liver function tests, B. S. P. test, serum transaminase value and icterus index were more higher in V-group than in A-group. According to the results above mentioned, I was convinced of that there were differences between histologic findings of the hepatic lesions caused by alcohol and viral hepatitis, the two main pathogenesis of liver cirrhosis.
- 千葉大学の論文
- 1966-07-28