てんかんの臨床経過と脳波変動について
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概要
- 論文の詳細を見る
113 epileptics who had never been treated before, were followed up for more than 3 years under regular medication. Pre-therapy recording were strictly made without medication, but later recording under it. Results were as follows : 1) Seizure discharges were evaluated topographically-those are diffuse, focal, diffuse+focal and absent. After the age 14 to 17 years, the patients without seizure discharges were clearly increased. The incidence of diffuse seizure discharge varied with age and its peak was at 10 to 13 years of age, whereas, focal one didn't seem to be influenced by maturation. 2) Basic rhythms were divided into 3 patterns in consideration of frequency, morphology and abundance of various waves. Of the pre-therapy recording, normal pattern was in 43 cases (38.0%), dysrhythmic in 41 (36.3%) and slow in 29 (25.7%). The dysrhythmic pattern which was most prominent at age of 10 to 13 showed a tendency to turn later into the normal pattern, therefore both patterns closely related to maturation. However, the slow pattern didn't show difinite alteration with age. Because of the markedly difference of age alteration between the dysrhythmic and slow pattern, it was presumed that the slow waves seen in the basic waves of epileptics were distinguished in two types. 3) Patients without seizure discharge had a good prognosis about to seizure control. Those with focal seizure discharges were having frequent seizures at follow up, whereas, those with diffuse ones had a few seizures. Although the patients with both seizure discharges were very few, they showed difinitely poor prognosis about to seizure control and social adaptation. 4) In the prognostic value of EEG findings in epileptics, the basic rhythm would be a more important factor than the seizure discharge. The transition to slow pattern and the persistence of it related to a significantly poor prognosis in both seizure control and social adaptation. The persistence of dysrhythmic pattern related to poor prognosis as to only seizure control. The appearance of the normal pattern was the sign of good results. 5) Among the 12 subgroups of EEGs based on the combination of basic rhythm (3 patterns) and of seizure discharge (4 types), those of normal basic pattern without seizure discharge and of dysrhythmic basic pattern with diffuse seizure discharge showed higher percentage, while other groups of various combination were also seen in fewer. And the EEG alteration of each subgroup was widely diverged. 6) It was considered that the maturation process and the epileptic process determined by various factors (age of seizure onset, degree of brain damage, etc.) may play important roles in the EEG alterations mentioned above.
- 千葉大学の論文
- 1966-05-28