最近5年間における心冠拡張薬,および,抗狭心症薬の臨床的薬効分析
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概要
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Clinical evaluation of eleven sorts of coronary dilating and antianginal drugs was performed acutely as well as chronically on 243 cases of ischemic heart disorders with special reference to cardio-vascular dynamic analysis, ecg, beg, blood chemistry, subjective complaints and side-effects. Results 1. The cardio-vascular dynamics: Stroke and minute volumes were reduced in most cases with Nitroglycerin and Coralgil in contrast with other kinds of the coronary dilators which augmented more or less these two values. Among these dilators, only Coralgil increased volume elasticity coefficient and blood streaming resistance. MAOI and Amplivix did not show any difinite effects on volume elasticity coefficient and blood streaming resistance. Blood pressure was slightly raised with Coralgil and Recordil, whereas it remained unchanged or rather lowered with other kinds of the drugs. In cardiac dynamics, Recordil often enhanced "pressure reaction" in Blumberger's sense while other remaining drugs lessened it. Heart rate was increased with Nitroglycerin, but it was not so markedly influenced with other drugs. In atrial fibrillation, the preceding cardiac cycle length-stroke volume curve was shifted right upwards by intravenous administration of Segontin. In general, these tendencies of improving hemodynamics were found more strikingly by acute use than chronic one. 2. Ecg : Eleotrocardiographic patterns remained unchanged in ten cases by the administration of Nitroglycerin. One case showed improvement of the T wave. Amplivix showed improvements of ecg only in three of eighteen cases. The other .drugs showed far more favourable effects. However, PQ-interval was prolonged by acute administration of Isoptin in fourteen of eighteen cases. 3. Beg : Segontin improved the ballistocardiographic findings in four of eight cases, whereas Amplivix in six of eight cases. 4. Exercise test: Segontin improved the tolerance to the exercise test in two cases and aggravated in one of four patients. MAOI caused marked increase in tolerance only in one case. The induced anginal pain was completely suppressed only in one case by the use of Nethalide. 5. Blood chemistry: The anticholesterinemic effect of Coralgil became increasingly in sixteen cases with dosage beginning from the ordinary dosis. The increase in blood cholesterol was, however, found in one case despite of the use of Nethalide. 6. Side effects : Acute administration of Persantin caused nausea, palpitation and headache. In a few cases, Nethalide caused dizziness. During the chronic use of Persantin, the loss of appetite was seen only in one case. With Segontin the scintillating scotoma, only transitory it was, or exanthema was observed in each one case. MAOI caused decrease in diuresis in two cases, euphoria in one case and the slight tendency to orthostatism in a few cases. Nethalide produced a granuloma at the site of injection in one case. The loss of appetite (twelve tablets of Coralgil pro die), impotency (Recordil), or meteorism (Perflavon) was observed in each one case.
- 1966-01-28