迷走神経胃壁発射にみられる周期性群発射について

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Adult dogs, anaesthetized by thiopental sodium, were used. The right cervical vagus was cut peripherally to ganglion nodosum in the upper part of the neck and the peripheral stump was separated untill the afferent nerve fibres originating from the receptor in the gastric wall showed the unitary spike. The stomach was distended with the air-charged balloon. From such fibre preparations, impulses during maintained gastric distension were recorded. In some fibres, burst and pause of discharge recurred periodically. Such type of discharge pattern was described here as periodically intermittent discharge, in which the relation between gastric distension and impulse activity was pursued. Therein, gastric distension was represented by gastric content in terms of volume and impulse activity by the total number of impulses during stomach discharge period (sum of the duration of burst and pause of discharge) from following two reasons. Firstly, analysis of discharge pattern showed that, when the degree of stomach distension became higher, the duration of burst of discharge became longer, that of pause shorter, while stomach discharge period showed only slight change. Secondly, experiments suggested that, in the fibres in which the response to maintained distension of the stomach was expected to be a slowly adapting discharge, the above-mentioned type of discharge pattern came into existence under the influence of peristaltic movement in and around the site of the receptor. Thus, the relation between the increase of gastric content and that of total number of impulses during stomach discharge period was found nearly proportional and two sorts of values, 22.5 impulses/50cc and 161 impulses/50cc, were regarded as proportional constant.
千葉大学の論文
1965-05-28

著者

明石泰雄
千葉大学医学部第一生理学教室

迷走神経胃壁発射にみられる周期性群発射について

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