頸動脈洞壁神経発射のパターンにかんする二・三の観察(<特集>脳と神経の研究)
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Fifteen dogs, weighing 6-15kg., were anesthetized with intravenous sodium thiopental 12.5mg per kg., and a tracheotomy with an artificial respirator was performed. Right Hering's nerve preparation was obtained by Miura's method. A functional single fiber of the nerve was put on the silver electrode, and its electrical activity was introduced to the cathode ray oscilloscope after adequate amplification. Intrasinusal pressure was measured by a catheter inserted via the lingual artery. An intact buffer nerve system served for observing its effect on the impulse activity of carotid sinus baroceptors. The interval diagram enabled us to observe the pattern of carotid sinus wall nerve discharges. The following correlations were demonstrated : a. systolic pressure gradient and the rate of change of spike interval b. pulse pressure and maximal frequeecy of impulse activity c. systolic pressure gradient and maximal frequency of impulse activity Within a normal intrasinusal pressure range, presystolic pressure, pulse pressure, and a systolic pressure gradient were the three major determinants in the pattern of impluse activity. Generally, maximal frequency of impulse activity depended on the level of presystolic and pulse pressure. Systolic pressure gradient influenced the rate of change of spike interval. These relationships, however, were altered by a marked change in blood pressure due to the administration of several pressor agents (e. g. epinephrine, norepinephrine or hypertensin II). During pressor responses, altered vascular tone plays an important role in generating the specific impulse pattern. From this point of view, aconitine and protoveratrine were used to change the tonus of the carotid sinus wall. Aconitine produced very particular impulse patterns, which suggested tonic and clonic changes of the carotid sinus wall tonus. Protoveratrine also produced characteristic impulse patterns suggesting a coninuously increased tonus of it. In summation, the pattern of carotid sinus wall nerve discharges should be analysed by using parameters which well reflect changes in the carotid sinus wall tonus.
- 千葉大学の論文
- 1964-09-28
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