肝炎,肝硬変症に於ける血清蛋白像に関する臨床的研究 : 附:肝硬変症及び其の他腹水を来す疾患の腹水蛋白像について
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概要
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Paperelectrophoretically estimated serum protein fractions conteining conjugated fractions -glycoprotein, lipoproteins & phospholipidprotein-in hepatitis & liver cirrhosis in every types & stadium of the diseases were studied with referrence to liver function tests. Decrease of alb. & increase of γ-glob. were observed relatively common in acute or subacute hepatitis, the more frequently & severely in chronic hepatitis. In cholangiolitic hepatitis increase of α_<1^->, α_<2^->, β-glob. were remarkable, and the changes of these each fractions generally coincided with increase of α_1, α2 glyceprotein, lipoprotein β or phospholipidprotein β. And also relationship with increase of α_<1^->, α_<2^->, β glob. & fructuations of serum alkalin phosphatase, serum mucoprotein & sepum copper level was observated. In every type of liver cirrhosis decrease of alb. & increase of 7- glob, was generally observed, severer in patients with ascites. Biliary or cardiac cirrhosis showed increase of α_<1^->, α_<2^->, β glob, relatively frequent, though postnecrotic or portal cirrhosis, sever cases particularly, showed decrease of these fractions. Glycoprotein fractions showed similar changes to protein fractions. Lipoprotein & phospholipid fractions showed decrease of fractions. In patients with ascites, mainly liver cirrhosis & carcinoma of liver, stomach & pancreas etc., ascitic protein fractions, also containing conjugated protein fractions, varied in every type or stadium of diseases, and suposedly influenced not only by serum protein fractions, but particularly in cases of carcinoma, by many factors in peritoneal cavity.
- 千葉大学の論文
- 1963-11-28