関節液の糖蛋白体並びにVitamin Cに関する研究
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The results of this study were based on the quantative analysis of mucosaccharide and vitamin C of synovial fluid aspirated from several different diseases of 99 human knee joints of 83 cases, and which were compared with those of 5 normal cases. Mucosaccharide was analysed by mean of the target of hexosamin- - -fraction I from hyaluronic acid by acetic acid, fraction H from glycoprotein by trichloracetic acid and fraction III from supernate. Elson Morgan's and Roe-Terauchi's techniques were employed for quantative analysis of mucosaccharide and vitamin C respectively. 1. Fraction I--Hyaluronic acid ; Decrease of this fraction is observed in the fluid of rheumatoid arthritis and tuberculous arthritis, and especially in traumatic arthritis. 2. Fraction II.--Glycoprotein ; Comparing with normal cases there is an increase in amount of this fraction in the fluid of affected knee joints ; rheumatoid arthritis and tuberculous arthritis. Rise and fall of serum glycoprotein is parallel with those in synovial fluid, which is considered due to the permiability of synovial membrane that has close relation with the degree of inflammatory changes of knee joints. 3. Fraction III--Mucoolygosaccharide ; There an increase of this fraction in affected knee joints, especially much increase is observed, in rhematoid arthritis. Because of fraction HI increases by depolymerization of hyaluronic acid with hyaluronidase, and decreases by polymerization of hyaluronic acid with cortison, this fraction is composed of the low polymerized molecules. 4. Total hexosamin ; Decrease of hexosamin is observed in affected joints, especially in traumatic arthritis, but this does not vary each other in several diseases. 5. Vitamin C ; Total amount of vitamin C reflects the pathological condition of joints, and increase of the difference of vitamin C between synovial fluid and serum is little in affected joints in contrast to normal cases. Study of mucosacchride and vitamin C is worth mentioning to determine the diagnosis and prognosis of the disease of the joints.
- 千葉大学の論文
- 1963-01-28
著者
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