中毒発現に及ぼす環境の影響に関する実験的研究 : 特に硫酸銅並びにオルトニトロクーロルベンゾールによる中毒に就いて
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概要
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By utilizing airconditioning apparatus, moderately high temperature and humid environment with mean temperature of 31.4℃ and mean humidity of 90.6 % was artificially produced. While keeping rabbits under such an environmental condition, Copper Sulfate in dose of 2.0〜4.0 mg/kg and ortho-Nitrochlorobenzene in. dose of 10〜20 mg/kg were injected to them. Another control group of rabbits was kept under natural environment and the above toxic agents were injected in the same amount. By comparing the effect on the two groups, the environmental influence on the appearance of poisoning was investigated. The results obtained were as follows. 1. Effect of Copper Sulfate injection. 1) Anemia was observed. After about 30 injections, the degree of anemia was more marked under high temperature and humid environment and the more toxic agent was given, the more severe the anemia. 2) Change of leucocyte count was variable and no definite change was seen in hemogram. 3) Enlargement of spleen and adrenal gland were seen with no relation to environmental difference. 2. Effect of ortho-Nitrochlorobenzene injection. 1) On the 12th injection, the degree of anemia was proportional to the quality of environment and the quontity of toxic agent, and significant difference was found. However, on the 36 th injection, no definite difference in the effect was seen regardless of the quality of environment and the quontitative variation of toxic agent. 2) Change of leucocyte count was variable and no definite change was found in hemogram. 3) In serum protein fraction and liver function, difference due to environment was not seen.
- 千葉大学の論文
- 1960-11-28