視床下部漏斗室内注入による諸種薬物のガマ骨格筋ならびに血圧におよぼす影響
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概要
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The purpose of this study was to determine the effect of hypothalamic injection of various drugs on the skeletal muscles, as well as blood pressure, hear rate and the peripheral blood vessels. Their central action is discussed. 1. Results of the experiments have shown that the drugs can be divided into the following groups according to their action on the circulatory system : a. Those which produce an elevation of blood pressure, an increase in heart rate, and peripheral vasoconstriction (adrenalin, atropine and vitacamphor). b. Those which produce an elevation of blood pressure and peripheral vasoconstriction, but a decrease in heart rate (acetylcholine and vagostigmine). c. Those which produce a transient fall of blood pressure followed by its elevation, and which have no effect on heart rate (picrotoxin and strychnine). d. Those which produce a marked elevation of blood pressure and a marked increase in heart rate, with no definite action on the peripheral blood vessels (urethane and phenobarbital). e. Those which produce a fall of blood pressure, with little action on heart rate or the peripheral blood vessels (mephenesin and d-tubocurarine). 2. The effect of hypothalamic injection of phenol, caffeine, picrotoxin, strychnine, d-tubocurarine, tetraethylammonium and mephenesin on the tonus of the skeletal muscles was determined by estimating the degree of tonus and the change in the action potential of the gastrocnemius. All the drugs used, with the single exception of mephenesin, produced convulsion and an increase in spontaneous discharge of the gastrocnemius. Blocking of the sympathetic and parasympathetic nerves had little effect in counteracting this action of the drugs. Administration of anesthetics, however, produced abatement or disappearance of the phenomena. Results of the experiments seem to indicate that the hypothalamus exerts a certain degree of control over the circulatory system and the tonus of the muscles in toads.
- 1960-11-28