視床下部漏斗室内薬物注入時におけるガマ血清内電解質イオンの変動について
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Experiments were carried out in toads to study the effect of hypothalamic injection of various drugs on serum K, Ca and Na concentrations. The drugs were injected into the vein and lymphatic sac also, so that results for each method of administration were compared with one another. 1. etermination of serum K,' Ca and Na concentrations was carried out during the period from November to April when toads hibernate. K and Ca did not show an appreciable change except for a decrease in February, while Na continued to decrease till April after a marked increase in January and February. For better understanding of the action of these drugs, their effect was investigated during the two periods, the former and the latter, with February as a dividing line. 2. Hypothalamic injection of acetylcholine caused Ca to increase during the former period and decrease during the latter period, while it caused K to decrease during both periods. Adrenalin produced an increase in K and a decrease in Na regardless of period. 3. When acetylcholine was injected into the lymphatic sac, K and Na behaved in the same manner as when the drug was injected into the hypothalamus, but Ca showed an increase during the latter period. When adrenalin was injected into the lymphatic sac, the electrolytes increased after showing a tendency to decrease at the initial stage. 4. When picrotoxin was injected into the hypothalamus or the lymphatic sac, K and Ca increased markedly during the former period, but their increase was not so marked during the latter period. Na increased during the former period and decreased during the latter period. 5. Na increased when strychnine was injected into the hypothalamus or the lymphatic sac, but K and Ca did not show an appreciable change during the latted period. 6. Hypothalamic injection of urethane did not produce an appreciable change in K, Ca and Na, while injection of it into the lymphatic sac produced a marked increase in K.7. When phenobarbital was injected into the hypothalamus, there was an increase in Na, but no appreciable change in K and Ca. Injection of it into the lymphatic sac resulted in a slight increase in K and a slightly marked decrease in Na. 8. When injected into the hypothalamus, atropine, vitacamphor or typhus vaccine did not produce an appreciable change in serum electrolytes. However, tetraethylammonium caused Ca to increase at the initial stage, returning to normal afterward, and K to increase gradually during the former period. These changes were not aspreciable during the latter period. 9. Hypothalamic injection of d-tubocurarine produced no appreciable change, except for a transient decrease at the initial stage. 10. Preliminary administration of picrotoxin, strychnine, urethane or phenobarbital counteracted the action of acetylcholine to produce a change in K. 11. Following preliminary administration of picrotoxin, intravenous injection of acetylcholine caused Ca to show a tendency to increase and Na to show a diphasic response. Following preliminary administration of strychnine, it produced no appreciable change in serum electrolytes. 12. Preliminary administration of picrotoxin or strychnine strengthened the action of adrenaline to cause a decrease in Ca. Following preliminary administration of urethane or phenobarbital, intravenous injection of adrenalin caused Ca to show a diphasic response. 13. Labelled P32 was injected into the hypothalamus, lymphatic sac or vein to investigate the distribution of P32 in various organs. Hypothalamic injection of the isotope resulted in a high uptake by the brain tissues. When the isotope was injected into the lymphatic sac or vein, however,, the liver and kidneys showed a high uptake, but there was little concentration in the brain tissues and spine.
- 千葉大学の論文
- 1960-11-28