人体末梢神経最大興奮伝導速度の研究 : 特に環境条件の影響に関する知見
スポンサーリンク
概要
- 論文の詳細を見る
The conduction velocity of the nerve fibers is believed to indicate their excitability. By applying submaximal stimuli to the peripheral nerves, I have estimated their conduction velocities in normal persons and patients with the disturbed nerves. The conduction velocities of the peripheral nerves of normal persons at room temperatures ranging from 20° to 24℃ were as follows : The efferent fibers of the ulnar nerve…N = 52 59.4±6.2m/sec The efferent fibers of the tibial nerve…N = 48 45.8±4.9 m/sec The efferent fibers of the sciatic nerve…N = 20 56.4±4.1 m/sec The efferent fibers of the sciatic nerve…N = 20 68.2±6.0m/sec The variance in the estimated values was thought due to differences in environmental conditions. So experiments were carried out to evaluate environmental factors, such as temperature and oxygen supply, affecting conduction velocity. The following observations were made : When the forearm was warmed, there was an increase of 1.8m/sec in the conduction velocity of the ulnar nerve per 1℃ raised in the temperature of the tissues surrounding the nerve. When it was cooled, there was a decrease of 3.8 m/sec per 1℃ lowered in the temperature. Ischemia of the forearm caused artificially produced a decrease of 6.9 m/sec in the conduction velocity per 1℃ of the temperature lowered. Ischemia, which causes deficiency in oxygen, had the greatest effect on the conduction velocity. Changes in conduction velocity produced with atropine, pilocarpine, adrenaline and chlorpromazine appeared primarily due to a change in body temperature caused by them. Daily fluctuations in the conduction velocity of the ulnar nerve in normal persons were within the range of estimating errors so long as the temperature of the tissues surrounding the nerve was kept at the same level. Conduction velocity paralleld to a certain degree nerve disturbance in patients with such disease.This observation is significant, for it warrants the clinical application of conduction velocity as a guide to prognosis of the patients. In one patient with idiopathic multiple neuritis, however, there was a marked fall in responce time and conduction velocity, though the patient's condition had improved rapidly and paralysis was almost gone. This seems to indicate the existence of the mechanism of muscle fiber reinnervation based on the branching of the residual uninjured nerve fibers.
- 千葉大学の論文
- 1960-11-28