未治療肺結核患者に関する臨床的研究 : 入院化学療法の検討

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In order to study the effect of chemotherapy, antituberculotic drugs were given to 194 patients with pulmonary tuberculosis who had received no treatment at all before, and the treatment was evaluated by determining the type of disese of each patient before and after the treatment according to J. S. C. classification. The following results were obtained : 1. Prior to the treatment, most patients had lesions of type A or B, with about one third of them having cavities, mostly cavities with walls that had not become hardened yet. 2. The treatment caused a decrease in the number of patients with lesions of type A, B or F, and an increase in the number of patients with lesions of type C or D. It led to the disappearance of cavities in about half of the patients with them. But cavities with hardened walls remained unhealed. 3. Patients with lesions of type A or F or with cavities of type Kc, Kx or Kz were associated with a variety of clinical symptoms. Sputum with tubercle bacilli, cough and expectoration, and accelerated erythrocyte sedimentation rate were seen more frequently in patients with cavities than in those without them. Parallelism existed between X-ray findings on one hand and the result of sputum examination for tubercle bacilli, erythrocyte sedimentation rate, and the volume of sputum on the other. 4. The results of the treatment were gradated as follows : the effect I or II was achieved mostly by patients with lesions of type A or B ; the effect HI by patients with lesions of all types ; the effet IV largely by patients with lesions of C, D or F ; and the effect V by patients with lesions of all types except type D, though they were small in number. 5. At least twelve months should elapse following the administration of chemotherapy before any attempts are made to determine its effect. 6. Chemotherapy had no effect in 35 patients, 18.1 per cent of the total. The result of a treatment seems to depend largely on the type of lesion. It also seems to have some relation to age, circumstances leading to the discovery of disease, the length of time from the discovery of disease to the institution of treatment, and family history.
千葉大学の論文
1960-09-28

未治療肺結核患者に関する臨床的研究 : 入院化学療法の検討

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