無菌海〓に於けるL. bifidus感染に関する研究

概要

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Of all the intestinal bacteria to be detected in guinea pigs, Lactobacillus bifidus is the most numerous. L. bifidus may exert a favorable influence on the growth of the host animals. To prove this, experiments were carried out in germfree guinea pigs, to which the organisms were given orally and their growth was compared with the growth of the controls. Oral administration of L. bifidus markedly accelerated the increase of body weight, indicating that it affects the growth favorably. The M_1 strain of Escherichia coli, which invariably kills germfree guinea pigs by causing sepsis, did not cause any fatal disease in the germfree guinea pigs to which L. bifidus had previously been administered orally. This seems to indicate that L. bifidus, once lodged in the intestines of germfree guinea pigs, has an inhibitory action on pathogenic organisms that may later invade the host animals.
千葉大学の論文