正常並びに異常人胎盤中のナトリウム・カリウム含有量
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概要
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1. Sodium and Potasium concentrations were determined in 119 human placentae of various kinds, using flicker photometer. 2. Values found in normal placentae at the end of the tenth month of gestation were: 190.4 mg % for Na and 204.2 mg % for K. The K levels are much higher than the levels reported by several investigators in the literature. Considering the values found in animal placentae and other human organs, they do not seem unreasonable. 3. In normal immature placentae, figures for Na increased gradually till the fifth month, when they began to decrease, falling slightly between the sixth month and the end of the term. On the other hand, figures for K increased since the beginning of gestation, reaching the highest level in the sixth month and dropping sharply in the seventh month. After that, they began to increase again, and the tendency continued till the end of the term. The fall in Na and K levels coincides with the developmental phase of fetal tissues with high Na and K content. 4. Toxemia of Late Pregnancy. Na and K levels in mild cases of Preeclampsia were nearly the same as in normal pregnancy. In severe cases, figures for K were raised, and those for Na were slightly lowered; and in eclampsia, figures for both Na and K were raised. In eclampsia, increased Na and K concentrations in the placenta were in keeping with increased serum Na and K concentrations. This increase seems to be due to changes in renal tubular function caused by increased DOCA from the placenta. 5. Figures for K were raised in severe cases of hyperemesis gravidarum. 6. In twin pregnancy, both Na and K concentrations were higher than normal as in toxemia of pregnancy. 7. The Placentae Praevia. In the placentae praevia, Na levels were normal but K levels were raised, as compared with the levels in normal placentae of corresponding month. Increase in K concentrations seems to be due to intraplacental hemorrhage.
- 千葉大学の論文