鉤虫Carrierの研究 : 第2編 五井保健所を訪ずれた鉤虫寄生者の一般血液所見
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概要
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Sixty persons free from diseases other than ancylostomiasis were drawn at random from among the males in the age group 20-30 who had visited for physical examination at Got Health Center in Chiba Prefecture, and the incidence of hookworm infection among them was determined. Hematologic examinations were carried out in them and persons free from hookworm infection, who serving as controls. They were divided into two groups, one patients with ancylostomiasis the other carriers. The results of hematologic examinations in one group were compared with the other group. Futhermore they were divided into several groups based on the kind and number of worms expelled, and the hematologic tests were compared from group to group. The following observations were made: 1. Persons visited Goi Health Center, who lived areas of high incidence of hookworm, infection had an incidence of 25 % of ancylostomiasis. Hookworm carriers unaware of the infection were found among the visitors at the rate of 1 in 3. 2. In ancylostomiasis group, persons harkoring more than 30 worms (determined by the numbers of worms expelled and counted in terms of A. duodenale) accounted for 50 of the total, with an average parasitism of 49 worms. In carrier group, many persons harbored 1 to 9 worms and none over 30 worms, with an average of 8 worms. 3. Even if free from any subjective symptoms, hookworm carriers were more anemic than controls, with a tendency to increased reticulocyte count. Marked anemic symptoms and increased reticulocyte count characterized patients with ancylostomiasis. Eosinophil cell count was increased in both groups. Leukocyte count showed no change. 4. Infection with A. duodenale alone or A. duodenale combined with N. americanus seemed to have a greater influence on blood picture than infection with N. americanus alone. Marked anemic symptoms, increased reticulocyte count and increased eosinophil cell count were noted in the former. 5. Influence of parasitism on the host was investigated and compared among the groups divided by the numbers of worms expelled, 1-9, 10-29, 30-99, and over 100 (in terms of A. duodenale). Results show that influence of parasitism grew with increased number of worms harbored. The influence seems to make itself felt when the number exceeds 30. 6. In carrier group, Proportion of hemoglobin had a close correlation with erythrocyte count and an inverse correlation with reticulocyte count, but its relation with eosinophil cell count was not established. 7. In carrier group, number of worms expelled had an inverse correlation with erythrocyte count and proportion of hemoglobin, and a correlation with reticulocyte count. These relationships were marked in persons harboring more than 30 worms. Number of worms expelled was not related to eosinophil cell count. 8. In view of results of the present investigation, it is hoped that health centers in rural areas should carry out tests for hookworm eggs in regular physical examination, and that a campaing should be organized on a large scale to clear their respective areas of hookworm carriers.
- 千葉大学の論文