Duhring氏疱疹状皮膚炎における組織学的所見および組織好酸球について
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概要
- 論文の詳細を見る
On the basis of the histological pictures of dermatitis herpetiformis, especially those of vesicles and/or bullae, taken from 16 cases, the author reached the following conclusions: (1) Primary intraepidermal vesiculation may occur in this dermatose. And it results presumably from localized spongiosis. In this series, 6 cases showed intraepidermal bullae and 4 of them had also subepidermal bullae. (2) Subepidermal bullae were seen in 12 cases, and were thought to be the standard bullae of the disorder. (3) Two types of subepidermal bullae are observed. One is tensioned bulla which is suitable for the term "pressure bulla", and the other is loose bulla which is caused by cleft formation at the dermal-epidermal junction. In the latter, cells forming lateral wall of bulla show normal appearances or hang in the bulla-cavity as if they were icicles. (4) It is interesting that sections from a 5 aged girl and 4 cases well over the age of 50 have shown only loose bullae. Because in elderly patients and in children the disease is prone to manifest itself by monomorphic large bullae. (5) The author considers that these two types of subepidermal bullae should be caused by the position of circulatory disturbance. (6) Acantholytic cells were often found in the bulla-cavity, especially in loose bulla. (7) Differential leucocyte count in the tissue infiltrate and in the vesicle was made. The differentiation between eosinophils and acantholytic cells was often difficult. The percentage of tissue eosinophils did not always increase in number in proportion to blood eosinophils. The grade of eosinophilia in the vesicle was more marked than those in the infiltrate in 9 cases, and the order was reversed in 2 cases.
- 千葉大学の論文