燐尿崩症の臨床的研究
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概要
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Clinical studies were made on 8 cases of phosphate diabetes which formed a half of the 16 cases of various forms of vitamin D resistant rickets seen in our department. The following results were obtained: Phosphate diabetes, which is a form of rickets characterized by chronicity and vitamin D resistant hypophosphatemia (phosphate content of the 'blood ranging from 2.1 to 4.2 mg＼dl with an average of 3.2 mg/dl), is associated with normal or less than normal calcium content of the blood (ranging from 5.1 to 11.7 mg/dl with an average of 8.83 mg/dl) and more than normal phosphate content of the blood (ranging from 17.0 to 32.0 S.J.R.U. with an average of 21.9 S.J.R.U.). Increased phosphate/calcium ratio in the urine (ranging from 4.0 to 37.7 with an average of 20.1), increased phosphate clearance value occurring selectively, and the finding of ATP<Kreatin PO_4 by P^<32> radioautogram of the hemolyzed red cells indicate this disease. Treatment of this disease with large doses of vitamin D has so far provided no satisfactory clinical results. Taking advantage of the action of parotin to promote the deposit of bone salts, we treated the cases under study with a combination of vitamin D (A.T.-10) and parotin. Of 8 cases treated, 5 were cured clinically and roentgenographically. The 3 cases that have been followed up over a long period (from 4 to 6 years) had recurrence of disease 12 to 15 months after the treatment had been terminated. In view of this, it would seem that an injection of 600,000 units of vitamin D per week can maintain a complete cure.
- 千葉大学の論文