糖尿病の水分代謝に関する研究

概要

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For the purpose of clarifying abnormal water balance in diabetes mellitus which assumes a very complicated character, clinical experiments were carried out in diabetes mellitus free from any complications to study phases of body fluids, renal clearance, water diuresis, and effects of various drugs on water diuresis mainly from the points of view of blood sugar levels and adrenocortical function. 1. Phases of body fluids, especially extracellular fluid, were affected in a great measure by changes in blood sugar levels. A close connection was recognized between phases of body fluids and adrenocortical function. 2. GFR was raised in diabetes mellitus. Changes in adrenocortical function and blood sugar levels had a marked effect on GFR, and a slight effect on RPF. 3. Adrenocortical function was demonstrated to be partly responsible for polyuria. 4. Water diuresis reaction depended to a great extent on the degree of hyperglycemia and adrenocortical function. 5. ACTH, predonine, cortisone and insuline had an action of promoting secretion of the urine in cases in which elimination of water following its ingestion was delayed, while glucose acted as an inhibitor of secretion ef the urine. The present study shows that the supraopticohypophysealadrenocortical system definitely takes part in water balance in diabetes mellitus.
千葉大学の論文