未熟児に於ける血中游離コリン体の臨床的研究

概要

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By using the biological methods developed by Kahlson and Chang & Gaddum, free choline content of the blood was determined in newborn infants, as well as their mothers at the time of delivery. Free choline content of the blood of mothers at the time of delivery was 0.043 mg/dl on an average, which was markedly lower than 0.28 mg/dl, the average value for normal adults. In free choline content of the cord blood, mature newborn infants' average was 0.21 mg/dl, while premature newborn infants' was 0.24 mg/dl, both values being markedly higher than normal infants' 0.14 mg/dl. In mature infants, free choline content of the blood suddenly began to fall within 24 hours after birth (down to 0.06 mg/dl), but it showed an early improvement, rising to 0.13 mg/dl on the 7th postnatal day. In premature infants, it began to fall about the 7th postnatal day and reached the lowest level on the 14th postnatal day (0.05 mg/dl). It took considerably long to improve, rising to 0.1 mg/dl on about the 21st postnatal day. Oral administration of choline chloride in a dose of over 40 mg per kg bodyweight per day had the effect of preventing the lowering of blood free choline levels in premature infants. Adequate doses ranged from 60 to 80 mg per kg bosdyweight per day. It seems that administration of choline chloride has favorable effect on the increase of bodyweight in premature infants.
千葉大学の論文