急性催眠剤中毒の臨床的研究 : 特に肝機能に就いて

概要

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Examination of the liver function is performed in 50 cases of hypnotic poisoning admitted the National Chiba Hospital during these two years (from Jan. 1956 to Desc. 1958), and gives following results: 1. Latent jaundice noted 31 in 50. Parenchymatic damage of the liver may cause an increase of serum bilirubin. 2. 42 in 50 show a urobilinogen in urin. 3. 42 in 50 present an abnormal B. S. P. test. 4. 46 in 50 give positive thymol tubidity and 30 show positive Gross reaction, there is, however, not a high grade of abnormal colloidal reaction. 5. Serum protein increases slightly in the maximam stadium of poisoning, and then the protein gradually decreases. Decrease of albumine and increase of globulin is noted and A/G is reduced. Alpha-globulin increases gradually and shows maximum within 72 hours after intake of the drug, and after 72 hours alpha-globulin decreases gradually. Beta-globulin shows nothing unusual and gamma-globulin increases but within normal limits. 6. Alkali-phophatase gives unchange. 7. .Serum iron shows in normal limits, there is, however, reduces gradually by the time going. The above noted results show a damage of secretion, excretion and metabolism of protein of the liver. In addition, these results prove clinically a diffuse parenchymatic damage of the of liver.
千葉大学の論文
1959-09-28