脾機能亢進に関する臨床的並びに実験的研究
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概要
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The purpose of the present studies is to elucidate the relationship between anemia producing substances to be detected in those patients to whom splenectomy is recommended arid hypersplenism that has been propounded by the investigators of American school. The presence of anemia producing substances in the sera and urine of 3 patients with thrombopenic purpura, who had exhibited panhematopenia, a condition attributed to hyper-splenism, was proved by inoculating rabbits with the sera and extracts of the urine of these patients. These two substances, however, were not identical. The sera were shown also to have the action of reducing blood platelets. Experiments were carried out in rabbits to study possible changes in the cellular elements of the blood, which occur as a result of splenic dysfunction caused by splenomegaly produced experimentally by ligating the veins of the spleen. In 2 to 14 days following the operation, anemia developed. The samples of sera of the rabbits operated on, obtained 2 to 9 days after the operation, showed the action of decreasing erythrocytes in the samples of blood from normal rabbits. Rabbits were intravenously injected with a physiologic saline solution containing 3 % India ink, in order to cause blocking of the reticuloendothelial system. The animals were divided into two groups, one group receiving 0.5 cc of the solution per kg of body weight once a day and the other group receiving 0.3 cc per kg body weight twice a day. Blood samples obtained from them began to show a reduction in the number of erythrocytes and the amount of hemoglobin 20 days after the injection had begun in the former group and 9 days after the injection had begun in the latter group. Anemia progressed as the injection continued. The samples of sera, obtained from the rabbits of the former group 145 days after the injection had begun, were shown to have an anemia producing action. Autopsy revealed an increase in weight of the spleens of these animals. Anemia, the presence of an anemia producing substance in the serum and enlargement of the spleen are the findings common to all humans and animals under studies. While what they call hypersplenism is assumed to be responsible for them, the concept of hyper-splenism should apply not only to the destruction of the cellular elements of the blood by a substance produced by the spleen, but also to the action of an anemia producing substance in the body fluids.
- 千葉大学の論文
- 1959-09-28