化粧品皮膚炎に関する一考察
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概要
- 論文の詳細を見る
I had attention in our clinic for several years that higt rate of woman face dermatitis would be of cosmetic origin. I attempt to clear up the causes of cosmetic dermatitis and examined some etiological factor in cosmetic cream. I studied 101 cases which supposed the cosmetic causes in their history. The main site of predilection were cheek, eyelid and neck, but also seldom appears on the dorsal surface of the hand and forearm. Most of them showed further sharply bounded fresh red erythema (25 cases); erythema, edematous papules, slight desquamation (67 cases); erythema, papules, vesicules, exudation and crusts (7 cases); pigmentation (2 cases), and all cases were usually acompanied with pruritus. The age of the patients were uaually in young woman, especially at 16-30 years, and the beginning of the disease were approximately 60 percent of cases at March to August. Such seasonable distribution may suggested the relation this disorder and ultraviolet wavelength. The patch test were performed in those patients with suspected cosmetics, its results showed 16.4 percent positive in cosmetic creams and 6.3 percent positive in cosmetic lotions. Three typical cases were presented in more detail. In some cosmetics, which were called medicated cosmetic cream, contained irritant substances such as Bismut or Mercury, and apparently this substances causes the contact dermatitis in some individuals, but at another cosmetic cream (except the speciality of contained Vitamins, Hormons or Proteins), these specific character would be considered upon the combined perfumes. It is prolable that some relation may present between cosmetic injury and ultraviolet ray of sunlight. I isolated the fluorescent substances with 10 percent hydrochrolic acid dilution and ether from each marketly creams, and estimated the intensity of fluorescent. All marketly creams showed the presence of more or less fluorescent substances, but its component were uncertain. However, the creams which contained no perfumes showed no fluorescent reactions, so I assumed the fluorescent substances might be in the combined perfumes. I investigated the intensity of fluorescent grade of 59 sort of natural or artificial oils of perfumes by fluorescent electrophotometer and recorded its colour by using "International Colour degree Table". Its result showed that the most strong fluorescent were noticed in Bergamott group than another. In animal experiments, I applied the patch test with absorptions ointment mixture of various percent of isolated fluorescent substances on the pinnes of rabbits, and irradiated the ultravioletaays. The animal experiment result showed apparently the causative significance compaired with contrast group. As I mentioned above, I assumed that one of the causative agents of cosmetic dermatitis were the photodynamic action of fluorescent suabstance in cosmetic cream, so I advice to the makers, it is necessary to select the perfume in order to avoid the cosmetsc dermatitis.
- 千葉大学の論文
- 1959-09-28