肺切除術後血胸成因に関する血管性因子の検討
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By using a new method for estimation of histamine, evolved in Pharmacological Department of our Univesity, a study was made on the relation between histamine and hemothorax, in order to determine the part which a vascular factor may play in the development of hemothorax following resection of the lung. In animal experiments using grown-up dogs, it was observed that performing thoracotomy and lung operation, as well as anoxia, caused histamine in the pulmonary veins to increase. In rabbits in which pleurisy and hemothorax had been experimentally induced, it was observed that the amount of histamine in the blood and thoracic exudation showed an increase immediately after induction of inflammation. Histopathologic investigation showed a multiplication of mast cells in the pleural cavity of rabbits in which hemothorax had experimentally been induced. There was an increase in the amount of histamine in the blood and thoracic exudation in 23 patients who had undergone resection of the lung ; some showed a sudden decrease, while some a gradual increase. A study made on the relation between the amount of histamine and the amount of blood lost during operation and aspirated after operation showed that the greater the amount of histamine, the greater was the amount of blood wasted during and after operation and the higher was a tendency to postoperative development of hemothorax. Histamine, having actions of dilating the capillaries and promoting their permeability and of lowering resistance of the blood vessels, may cause hemothorax to occur when it is abnormally increased in amount.
- 千葉大学の論文
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- 肺切除術後血胸成因に関する血管性因子の検討