疫痢に於けるヒスタミンの研究
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概要
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Histamine excreted in the urine was measured by Anrep's method in infants and children suffering from Ekiri and dysentery. It was shown that there was a marked increase in the amount of free histamine in the urine secreted for the first time following temporary cessation of urination in Ekiri, as compared with the amount of free histamine excreted in the urine in dysentery. In view of the fact that there was a lowering of the choline content of the blood in Ekiri, mice was fed on a diet low in choline and their sensitivity to histamine was tested. It was shown that they had become hypersensitive to histamine. It was also shown that they were hypersensitive to the Shigella endotoxin. Albino rats were grouped into the following four categories : those that were fed on a diet low in choline (group 1); those that were fed on a diet dosed with choline chloride (group T); those that were fed on a diet low in choline and were injected with the Shigella endotoxin (group 3); and those that were fed on a diet dosed with choline chloride and were injected with the Shigella endotoxin (group 4). Measurement of histamine detected in various organs of these animals showed that there was a marked increase in the amount of free histamine in the lungs and intestines of the animals of group 3. There was a decreased activity of histaminase in the serum in Ekiri. A decrease in histaminase activity was observed in the lungs, intestines and liver of the albino rats fed on a diet low in choline as well. It would seem that an increase in the amount of histamine, along with a lowering of the choline content of the blood, is a factor in the development of Ekiri.
- 千葉大学の論文
- 1959-03-28