腎機能検査法としてのキサントプロテイン反応の臨床的検討
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概要
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Since it was held in 1924 by Becher to be of value indetermining the degree of renal insufficiency and consequently in predicting the probable result of patients with renal disease xanthoprotein reaction test has had extensive clinical applications. In recent years, however, clearance test has established themselves as renal function test, and xanthoprotein reaction test has become somewhat outdated and less used than before. In order to review the value of xanthoprotein reaction test and to determine the position at present occupied by it among many renal function tests used as a diagnostic aid, various tests were performed and the results were compared. The normal value of plasma xanthoprotein reaction level was shown to be 17.9±0.6; plasma xanthoprotein reaction was normal in acute nephritis ; and it increased as renal function deteriorated in chronic and terminal nephritis. In renal diseases the increase in plasma xanthoprotein reaction levels occurred slightly after the increase in plasma urea-N and plasma creatinine levels. The increase in plasma xanthoprotein levels occurred when glomerulo-tubular unbalance took place, with the values of G.F.R., R.P.F., R.B.F., Tm_<PAH>, and Tm_G going down below 25cc, 150cc, 250cc, 25mg. and 100mg. per minute, respectively. It will be seen from the data produced by the present experiments that xanthoprotein reaction test is of no less value than other methods under consideration in determining the degree of renal insufficiency. It is also of value in diagnosing the onset of true uremia and forecasting the prognosis of patients with renal disease.
- 千葉大学の論文
- 1959-01-28