肺結核下痢患者におけるINH投与前後の腸内菌叢と腸運動について
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概要
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In an attempt to identify causative factors involved in the diarrhea in patients with tuberculosis, studies were made of the changes in intestinal flora following administration of INH, and movements of the intestinal tract were examined by cineroentgenography in the same patients. The results are summarized as follows : 1. Examinations of the feces from the tuberculous patients under study and those from the controls showed that the ratio coliform bacteria/enterococcus was smaller in the former than in the latter, and that lactin non-decomposing coli form bacteria increased in number in the former. Cineroentgenograms of many of the patients revealed the evidence of tension and hypo function of the intestinal tract as well as abnormal interruptions in the contour of the small intestine. These observations seem to indicate that the diarrhea associated with tuberculosis is caused by disfunction of the intestines and changes in intestinal flora occurring as secondary manifestations of tuberculosis. 2. After administration of INH for three weeks, all patients, with a few exceptions, were cured of diarrhea, and at the same time normalization of the ratio coliform bacteria/enterococcus and the ratio lactin decomposing coli form bacteria/lactin nondecomposing coli form bacteria occurred simultaneously with improvement of intestinal function steadily and progressively. 3. INH, when given to tuberculous patients with diarrhea, may counteract the poison of tubercle bacilli by causing improvement of tuberculosis, and may bring about reestablishment of the balance of intestinal flora and improvement of intestinal function. The cure of diarrhea seems to be- the result of these two complementary processes.
- 千葉大学の論文
- 1959-01-28