手術前後における小児の蛋白代謝
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By estimating serum protein and total nitrogen in the urine in 78 children under 15 as well as 20 adults, comparative studies were made of protein metabolism in children and adults in the pre- and postoperative periods. (1) In the majority of children with diseases requiring surgical "treatment, with the exception of hernia, serum protein findings were abnormal. There were hypoproteinemia and hypoalbuminemia in many of the children with ileus or malignant tumors. (2) The younger the children undergoing operations, the greater was the influence of operation on the serum protein fraction : there were a marked decrease in the percentage, of albumin and a marked increase in the percentage of -a-globulin in children in the postoperative period. It appeared that normalization of the serum protein fraction after operations occurred slightly earlier in children than in adults. (3) The amount of total nitrogen in the urine Cexpressed in mg per kg of body weight) in the postoperative period was far larger in children than in adults. Its amount was larger in many of the children who had undergone minor operations than in adults who had undergone gastrectomy. (4) It is desirable that the amount of protein given to children in the postoperative period should be over 4g per Kg of body weight a day. The oral administration of protein should, therefore, be begun at an earliest possible postoperative date. In the event this is impossible, the intravenous administration of protein following the opening of a vein may be of value in making the postoperative course uneventful. The results of the present studies would indicate that, though surgery evokes fairly serious metabolic responses in children, recovery in the postoperative period might occur earlier in children than in adults if an adequate supply of nourishment could be maintained.
- 千葉大学の論文
- 1958-11-28
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