ツベルクリン反応発現様式に関する研究 : 特に微弱反応を呈するものについて
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概要
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Popularization of periodic examinations to control tuberculosis has led to repeated injections of tuberculin at the same portion of the skin. Consequently, the so-called acceleration phenomenon has become a problem that cannot be made light of. By the acceleration phenomenon we mean the speeding up of the occurrence of reaction at the portion of the skin where such injections have often been made before. Under this phenomenon, the reaction is most marked 24 hours after injections and recedes thereafter, with redness in the skin fading and diminishing in size 48 hours after injections. The author studied this phenomenon to determine the factors concerned in it. Investigations were performed on the following subjects : (1) The relation of the occurrence of this phenomenon to the site of injections and the time after injections. (Injections were made on the flexor and extensor surfaces of one forearm, and reactions examined in 24 and 48 hours.) (2) The relation of the occurrence of this phenomenon to the site of injections. (Injections were made on the flexor surface of both forearms, and reactions were examined 48 hours after injections,) (3) The relation of the occurrence of this phenomenon to the numbers of injections previously made and the dilution of tuberculin. (Some of the persons tested had received injections for less than 4 times, some for from 5 to 29 times, and some for over 30 times. Both 2000 and 100 dilutions were used for the test, and the results were compared.) (4) Influences of the existence of tuberculosis, infection by Ascaris and any allergic disease on reaction to the tuberculin test. It was shown that the occurrence of the acceleration phenomenon was closely related to the use of the same portion of the skin as the site os injections, and that the oftener infections were made, the earlier became the occurrence of reaction.
- 千葉大学の論文
- 1958-11-28