眼圧調節中枢に関する薬理学的研究 : 諸種薬物のガマ視床下部漏斗室内注入の眼圧並びに血圧に及ぼす影響について(第1報)
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Report I There have been several hypothesis intended to explain the localization of the control center of the intra-ocular pressure. Since Magitot advanced a hypothesis that such center might lie somewhere within the diencephalon, this attracted the attention of numerous investigators. The author made a pharmacological study on the function of the hypothalamus in the control of the intra-ocular pressure in toads. Actions of various drugs on intra-ocular as well as blood pressure were investigated by injecting them into the recessus infundibulum in the hypothalamus. Toads weighing about 220gm. ware used in the experiments. Measurements of intraocular pressure were made by modification of Kondo's method under urethane anesthesia, and graphic tracing of intra-ocular as well as blood pressure was recorded simultaneously on a rotating photographic paper. Conclusions 1. Various drugs produced marked variations in intra-ocular as well as blood pressufe when they were injected into the recessus infundibulum in the hypothalamus. 2. Laying bare or mechanical stimulation of the hypothalamus, injections of frog-Ringer's solution, distilled water or Indian ink into the recessus infundibulum, or ligation of the large arterial vessel did not produce any changes in intra-ocular as well as blood pressure. 3. Electrical stimulation of various parts of the diencephalon and telencephalon revealed that the stimulation of the hypothalamus produced the most marked rise in intraocular as well as blood pressure. 4. A comparatively marked rize in the intra-ocular pressure was produced by methamphetamine, picrotoxin, strychnine, benzyl-imidazoline, phentolamine, acetylcholine, pilocarpine, 0.05 % neostigmine methylsulfate (Vagostigmin), 0.5 % atropine, 1 % T.E.A.B., promethazine and posterior pituitary hormone (atonin), when they were injected into the recessus infundibulum. Similarly, a gradual rise in the intra-ocular pressure was produced by epirenamine, eserine, nicotine and 0.1 % T.E.A.B. 5. Phenobarbital, 3-dimethylamino-l, 1-di (2'-resection of the telencephalon. 9. Removal of the anterior lobe of the pituitary gland produced a slight rise in intraocular pressure and a gradual fall in blood pressure. 10. In toads from which the anterior lobe of the pituitary gland had been removed, a rise in the intra-ocular pressure produced as a result of the injection of acetylcholine into the hypothalamus was less marked than in normal toads and it did not occur at all, while the drug produced no transient rise in blood pressure, but rather tended to lower it in the majority of toads. Pilocarpine produced more pronounced and sustained rise in intra-ocular pressure than in normal toads, while it did not lower blood pressure but produced its rise, both transient and sustained.
- 千葉大学の論文
- 1958-09-28
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関連論文
- 眼圧調節中枢に関する薬理学的研究 : 諸種薬物のガマ視床下部漏斗室内注入の眼圧並びに血圧に及ぼす影響について
- 眼圧調節中枢に関する薬理学的研究-2・3-
- 眼圧調節中枢に関する薬理学的研究 : 諸種薬物のガマ視床下部漏斗室内注入の眼圧並びに血圧に及ぼす影響について(第1報)