Wezler法および,Blumberger-Holldack法による物理学的心・脈管力学的分析の統計観察

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The statistical investigation upon the cardio-vasculo-dynamical analysis by means of Blumberger-Holldack's and Wezler's methods were performed in 77 cases of normal health and 102 patients suffered from essential hypertension, and then there were examined range of distribution, mean value, standard deviation and variation index etc.. According to Wezler-Boger's principle, 102 cases with essential hypertension were classified into W+E' type (61 patients), M (12), M+E' (12), W+E'+M (11), W (3); E' (2) and M+W (1) respectively. Tbl. 1 shows age, blood pressure level and vascular dynamical values of the whole observation. Respecting mean value M and standard deviation S of all circulatory dynamical factors, except for stroke volume Vs and minute volume Vm, there could be found the significant difference between normal health and essential hypertension. Concerning mean value of cardio-dynamical data and pulse rate, except for UFZ, there could be observed the significant difference between normal health and essential hypertension. Variation coefficient of DAZ estimated in both groups was distinctly larger than that of other cardio-dynamical data. This may be related to the minority of the absolute value of DAZ and moreover to the susceptibility to influences from the cardiac rate and tonicity of extracardiac nerves. In general, variation coefficient of cardiodynamical value tended to remain smaller than that of vasculodynamical value. Tbl. 3 shows the statistical value of blood pressure range observed in each hypertensive group classified by Wezler-Boger's principle; mean value of Ps Pd and Pm were found the least in M type, and no difference between two other types. Standard deviation was observed the largest in M+E' type and no difference between two other types. Regarding vasculo-dynamical date as shown in Tbl. 5, mean value of Vs and Vm can be put in order of their sizes, as M> M+E^W+E', while mean value of W, E' and pulse wave velocity C as W+E'> M+E'>M. Variation coefficient of blood pressure level was found the lowest in W+E' type, whereas the largest in M+E'. The variation coefficient of peripheral vascular dynamical data was observed the largest in W+E' type, while the smallest in M+E' type. The statistical investigation was performed in each hypertensive group classified by Keith-Wagener's method, that is, 36 cases belonged to I type, 50 to II, 27 to III; owing to the minority of IV type, this group was excluded. Tbl. 5 shows Wezler's data obtained in Keith-Wagener's I, II and III group. With the advance of Keith-Wagener's type, W+E' increased in their number. Respecting the blood pressure level as shown in Tbl. 6, mean value of Ps, Pd and Pm can be put in order of their sizes as Keith-Wagener's I, II and III type, and their standard deviations are found the largest in Keith-Wagener's III type. Concerning vasculo-dynamical data as shown in Tbl. 6, among groups classified by Keith-Wagener's method there can not be found any significant difference, but the largest Vm is observed in Keith-Wagener's I type. W, E' and c were found the least in I type, while they were seen nearly of equal size in H and HI type. Standard deviation in H type was larger than those in other types. As shown in Tbl. 6, the variation coefficient of blood pressure level is found the largest in HE type, the least in II type, whereas variation coefficient of vasculo-dynamical data was observed the largest in II type. Nextly, source and range of error in Blunjberger-Holldack's and Wezler's values were investigated. 40 cases of normal health and 41 suffered from essential hypertension (W+E' type) were calmly laid down, then the first determination was performed, thereafter at five minutes' interval the second and the third determination were undertaken. Change of their variation coefficients due to increase in number of examination was statistically observed. In Fig. 4, concering blood pressure, variation coefficient of the first determination is assumed as 100. In normal health, increase in number of the examinations somewhat reduced variation coefficient of systolic pressure, but augmented that of diastolic. In essential hypertension there could not be found any significant tendency regarding blood pressure value. Innormal health, increase in number of the examination reduces all variationcoefficients of vasculo-dynamical values as shown in Fig. 5, especially as to Vm, there can be seena 13% reduction. In essential hypertension the tendency to decrease was more marked than in normal health, but variation coefficient of Vm alone did not show any significant change. Respecting cardio-dynamical data as shown in Fig. 6, the variation coefficients of UFZ, DAZ, and ASZ tend to decrease more distinctly than those of vasculo-dynamical data, but there can not be observed any significant reduction concerning ATZ and Q-II time. In essential hypertension, variation coefficients decreased more markedly than those in normal health, especially as to DAZ, there was seen a 20% reduction in the former group, but concerning UFZ, there occured no significant change. Regarding ATZ and Q-II time, significant changes could not significantly be recognized.
千葉大学の論文
1958-09-28

Wezler法および,Blumberger-Holldack法による物理学的心・脈管力学的分析の統計観察

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