治療前後における心・脈管疾患の心拍量,とくに,Keys-Friedell法による研究

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The cardiac reserve is considered in terms of various factors. Among them., cardiac enlargement, systolic and diastolic reserve volume are mainly discussed as to various sorts of heart diseases in this paper. The modified procedures of Keys-Friedell's and Wezler's method were published in this Journal (Vol. 34 p. 579 '58) by our collaborator Umezawa. In this obervation the cardio-dynamics was studied by Blumberger-Holldack's principle which was investigated in this Journal by our collaborator Kinoshita (Vol. 34 p. 92 '58), Tachibana (Vol. 34 p. 130 '58) and Takahashi (Vol. 34 p. 615 '58). According to Keys-Friedell's and Wezler's methods, stroke volume and cardiac output of various heart diseases before and after treatments were determined, especially both diastolic cardiac volume and cardio-vascular dynamics were examined. 1. The direction of the changes of cardiac output due to the treatment with hypotensive drugs among essential hypertension were concordant, whereas those of Keys-Friedell's and Wezler's values were occasionally discordant in the cases with left ventricular strain curve electrocardiographically and lateral plateau x ray-kymographically. In the cases without left ventricular strain curve, even if the peripheral resistance was reduced, the cardiac volume remained unchanged or showed very little fluctuation. In the cases with strain curves or patterns of myocardial disturbance, when the peripheral resistance diminished, the cardiac volume decreased in the many and increased in the few. In the renal hypertension the tendency above mentioned could not obviously be formed. 2. During the course of congestive hart failure treated by digitalisation, followingresults were obtained as the advance of the recompensation. a. In mitral stenosis and chronic cor pulmonale, output estimated by two methods increased in their amount to the normal range and showed the pararellism among them. b. In mitral insufficiency, aortic regurgitation and combined valvular diseases, output determined by two methods did not show pararellism, possibly due to the existence of back flow, and despite of the treatment this tendency remained unchanged. c. In hypertensive cardiac disease the parareliism between two sorts of values failed to be found both before and after the treatment. 3. In hyperthyrosis and anemia, the treatment normalized the cardiac ouptut estimated by two methods and there was seen certain pararellism as to the mode of changes. 4. In coronary insufficiency there could not be any definite tendency between both cardiac output determined by two methods and peripheral circulatory dynamical values before and after treatment.
千葉大学の論文
1958-09-28

治療前後における心・脈管疾患の心拍量,とくに,Keys-Friedell法による研究

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