急性実験的心硬塞時における心,脈管,および,呼吸強盛剤の末梢循環分析

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The circulatory dynamics of experimental myocardial infarction of dogs was analysed by means of newly improved Prof. Wezler's method (1949) with special reference to the effects of various cardio-respiratory stimulants upon the hemodynamics at the e-mergency with due regards to "centralization". 1. Elastic (E') and peripheral resistance (W) were transitorily reduced soon after the ligation of coronary arteries or the cauterization of myocard. However the blood pressure did not usually showed the extreme decrease in its height so far as the augmented output (Vm) was concerned. The tendency to the shock diminished by the use of the anesthesia properly administered, as Revy et al. had emphasized in this sort of experiments. 2. The intravenous injection of Epinephrine arose markedly but temporarily the blood pressure level in the state on the verge of shock immediately after the experimental infarction. This elevation of the blood pressure is due to the increase in Vm, W, and E'. With this extent of the dosage, there could be often found the tendency to the respiratory inhibition. In Ecg, depending upon the severity of the experimental infarction, arrythmias developed by the administration of the Epinephrine more frequently than those in the undamaged hearts. 3. The effect of the elevation of the blood pressure was proved less potent in Neosynephrine than in Epinephrine, but its duration longer in the former than in the latter. The respiratory inhibition of Neosynephrine was found inferior to that of Epinephrine. The effect of Neosynephrine varied more largely according to the time point of the application soon after the experimental infarction than that of Epinephrine. 4. Suprif en showed the elevation of the blood pressure in the type of E'+W at this emergency without so marked respiratory inhibition. 5. Vasopressin showed at first the decrease in the blood pressure in the type of "Anspannungskollaps", and thereafter resulted the arterial hypertension in the type of W+E'. From the viewpoint of the cardiac efficiency, Vasopressin can not be regarded as the favourable drug for the treatment of the shock-like state of the experimental infarction, moreover, the large amount of Vasopressin appears to constrict the coronary vessels. 6. Pronestyl did not anyhow improve the peripheral circulatory dynamics itself. But the considerable benefit can be proved for the remedy of arrythmias or of tachycardia due to the experimental infarction. 7. So-called cardiac hormone (Cardinon "Teizo") showed usually the transitory hypotension in the type of "Anspannungskollaps". Therefore when there exists the danger of the circulatory collapse, much notice may be paid for its use with due consideration of the peripheral circulatory state, despite of some coronary dilatatoric action in perfused preparates. 8. Carnigen "Hoechst" consists of two different components, so that the mode of its action varies according to the dosage and the circulatory state at the application. 9. Lacarnol "Hoechst" showed the slight and transitory hypotension in the type of "Entspannungskollaps". The recovery of the blood pressure back to the initial level can be instantly seen by the augmentation of Vm. As to the respiratory state affected with Lacarnol, the trifling and merely temporary hyperventilation appeared immediately after the intravenous injection and then there could be found occasionally the small degree of the bradycardia which may be no obstacle for the clinical praxis even soon later the initiation of the attack. 10. The intravenous injection of Aminophylline decreased in the amount of Vm, W and E' and resulted, as a rule, transitorily the arterial hypotension. However Aminophylline has the respiratory stimulating action, therefore the inhibition of respiration does not occur in spite of reduction of blood pressure level. 11. There could be hardly observed any intended effect of π-oxo-Campher upon the cardio-vascular and respiratory state immediately after the experimental infarction. 12. Strophosid "Sandoz" elevated slightly the blood pressure at this emergency without any significant increase in Vm (Our catheter team had already reported by means of Bing's method that Strophosid rather reduces the oxygen consumption despite of the moderate increase in the coronary blood flow). The amplitude of the ventilation was occasionally augmented a little, presumably due to its secondary effect. Lanatoside C given intravenously did not show any benefitable effect upon the peripheral circulation immediately after the experimental infarction. Digoxin used intravenously in the state on the verge of shock reduced Vm, W and E' and showed also no favourable effect upon the respiration. 13. The intravenous injection of Coramin-Adenosin "Ciba" lowered transitorily the blood pressure range, this effect was counteracted with Neosynephrine administered simultaneously. Coramin-Adenosin enhanced the respiration as well as Theraptique. In Ecg, immediately after the injection of Coramin-Adenosin, there appeared the tachycardia in Ecg, which inhibited the bradycardia due to Neosynephrine applied at the same time. The experimental findings of Coramin-Adenosin above mentioned can be almost observed as well as in clininal praxis. 14. Hypertensive action of Theraptique exceeded often that of Neosynephrine, however the former was of shorter duration than the latter. Theraptique augmented firstly W, than Vm., and showed the remarkable respiratory stimulation which differs from the effect of Epinephrine used in considerable dosage. Various kinds of experiments were made in order to analyse the action mode, of Theraptique from which it may be concluded to be of the central origin as well as of the peripheral.
千葉大学の論文

急性実験的心硬塞時における心,脈管,および,呼吸強盛剤の末梢循環分析

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