疫痢に於けるコリン代謝の臨床的研究

概要

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The author carried out clinical studies on choline metabolism in ekiri. The results are summarized as follows: (1) Examinations of the ability of the fecal bacterial flora to decompose choline have disclosed that it is higher in patients with ekiri than in those witn dysentery. Of all the organisms detected in the feces of patients with ekiri, organisms of the genus Shigella, coliform bacteria and paracoli bacteria have shown high ability to decompose choline, while organisms of the Cl. welchii have shown low ability. (2) Urine trimethylamine levels were higher in patients with ekiri than in those with dysentery and normal children. (3) Increases in creatine and creatinine levels in the urine were larger in patients with ekiri than in those with dysentery. These observations would suggest that in ekiri choline undergoes decomposition in the intestines and the demand for it is increased as a result of the excretion of methyl radical in the urine. It would seem that these phenomena are among the factors responsible for the fall of free choline levels in the blood. (4) The excretion in the urine of choline chloride administered was smaller in amount in patients with ekiri than in those with dysentery. This observation would indicate that choline administered to patients with ekiri is made use of in the dody.
千葉大学の論文