軟骨内S代謝に関する実験並びに臨床的研究 : 第1編 諸種ホルモンの骨端軟骨内S代謝に及ぼす影響
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The present paper deals with the experimental studies on whether the amount of radioactive sulphur S^<35> accumulated in the epiphysial cartilage varies according to the differences in age, and on how it is affected by various hormones administered previously. (1) Injections of S^<35> into the abdominal cavities of normal albino rats deriving from the same female parent resulted in a rapid rise of its per cent dose per unit weight of the epiphysial cartilage and shaft (excepting the bone marrow); the dose attained the maximum value in about 24 hours and gradually decreased thereafter. (2) The per cent dose of S^<35> per unit weight of the epiphysial cartilage of normal albino rats was in inverse proportion to their age (and their weight); the older (the heavier) the animal, the smaller was the value. This was also the case with the relation between the weight of the epiphysis and the per cent dose of S^<35> per unit weight of epiphysial cartilage. (3) The per cent dose of S^<35> per unit weight of epiphysial cartilage of albino rats which, deriving from the same female parent and weighing 80-90 gm., had had the salivary glands removed one month previously, was more or less equal to the value of the control group. (4) The per cent dose of S^<35> per unit weight of epiphysial cartilage of both mature and immature normal albino rats, to whose abdominal cavities 1 mg. of parotin per kg. of body weight had been injected over ten times, reached the highest level 24 hours after the injections of S^<35>. This tendency was especially marked in immature rats. (5) The per cent dose of S^<35> per unit weight of epiphysial cartilage of two groups of albino rats-one group of rats had been fed on a diet containing 0.05 % of iodocasein for from ten to twenty days, and the other group had been injected with 0.01 mg. (0.5 international units) of methyltestosterone was slightly larger than that of respective control group (consisting of rats deriving from the same female parent) 12 hours after injections of S^<35>. (6) The per cent dose of S^<35> per unit weight of epiphysial cartilage of three groups of albino rats-the first group had been fed on a diet containing 0.1 % of methylthio uracil for 48 days, and) the second and the third groups had been injected with 5 mg. and 0.25 mg., respectively, of cortisone-was slightly smaller than that of respective control group 12 and 24 hours after injections of S^<35>. (7) The per cent dose of S^<35> per unit weight of the epiphysial cartilage of two groups of albino rats, which had been injected with 1.0 mg. and 0.1 mg., respectively, of ACTH for three days. was slightly larger than that of respective control group 12 and 24 hours after injections of S^<35>.
- 千葉大学の論文
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- 軟骨内S代謝に関する実験並びに臨床的研究 : 第1編 諸種ホルモンの骨端軟骨内S代謝に及ぼす影響