水利尿に及ぼす各種利尿剤の影響に就いて
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It is generally believed that restriction of the intake of sodium chloride is effective in the treatment of edema. There are, however, conflicting theories as to whether restriction of the intake of water is also effective. Work on physiologic diuresis caused by water intake has been done by several researchers. The author studied the influences of various kinds of diuretics on physiologic diuresis. The diuretic agents used in the study were 50 % hypertonic dextrose solution (given intravenously), a melamine compound (given orally), theophylline (given intravenously), a mercurial compound (given both intravenously and intramuscularly) and DIAMOX (given both orally and intravenously), which were administered to persons having Volhard's water test for renal function. Comparison of the results obtained in these persons with the results obtained in the control revealed the following findings: (1) Fifty per cent dextrose solution, which is an osmotic diuretic, had no direct effect on water diuresis. (2) A melamine compound, when given simultaneously with water, did not cause increase in the secretion of urine at dilution stage, but had diuretic effect specific to this agent at concentration stage, when there were increases in the amounts of Na and Cl, as well as in the volume of urine. (3) As compared with the control, persons given theophylline showed marked increases in the amounts of Na and Cl, as well as in the volume of urine at dilution stage. The effect of the drug lasted for four hours after administration. (4) Like theophylline, a mercurial compound caused increases in the amounts of Na and Cl, as well as in the volume of urine, at dilution stage. Being larger than the effect of theophylline, its effect lasted for six hours after administration. (5) Irrespective of whether it was given orally or intravenously, DIAMOX caused increases in the amounts of Na and K, as well as in the volume of urine, at an early stage. When given intravenously, it had immediate diuretic effect, though its administration did not result in an appreciable increase in the amount of Cl. It may be concluded from these observation that theophylline, a mercurial compound and DIAMOX have an action of promoting the secretion of urine in water diuresis.
- 千葉大学の論文
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- 水利尿に及ぼす各種利尿剤の影響に就いて