小児期に於ける血清並びに髄液の枸櫞酸量に関する臨床的研究
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概要
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Since the importance of citric acid metabolism has been discussed today, the author measured serum and cerebrospinal fluid citric acid levels by the method of Natelson et al. The findings of the investigation are as follows: (1) Among the diseases in children, the existance of hypocitraemia was observed in children suffering from pertussis, pneumonia, measles, mentaldefect, ricket, myxoedema, leukaemia and bile duct diseases. Also the existance of hypercitraemia was observed in children suffering from hyperthyroidism, liver diseases, "Ekiri" and diabetes mellitus. Children suffering from ruhr, acute dyspepsia, purpura and eczema manifested values with in the normal range. (2) The author conducted observation of the citric acid changes in the serum after citric acid had been intravenously administrated in normal and liver function damaged children. It obtained abnormal citric acid curves in liver function damaged children and had been suggested the disturbance of citric acid metabolism. (3) The average value of normal cerebrospinal fluid citric acid levels was 3.88±0.28 mg/dl. Higher cerebrospinal fluid citric acid levels were detected in all the cases of encephalitis japonica, tuberculous meningitis, and purulent meningitis. Lower cerebrospinal fluid citric acid levels were detected in all the cases of mental defect, hydrocephalus, epilepsia; and cerebral palsy. Children suffering from poliomyelitis, brain tumor, tetanus and tracheobronchial lymphnode tuberculosis manifested values with in normal range. It had been recognized that cerebrospinal fluid citric acid levels returned to the normal level according to the recovery of clinical symptoms in the cases of tuberculous meningitis. There was no correlation between citric acid and surgar levels in cerebrospinal fluid. (4) Higher serum and cerebrospinal fluid citric acid levels were recorded after citric acid had been administrated by orally, but there was no correlation between cerebrospinal fluid and serum citric acid levels increase rates.
- 千葉大学の論文