化学療法剤耐性結核菌についての臨床的研究

概要

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This report was made on 371 patients with moderately far advanced or far advanced pulmonary tuberculosis. They received the resistance examination of sputum monthly. The results are summarized as follows: 1) Under the chemotherapy, the tubercle bacilli became negative within 6 months after the beginning of treatment. If no bacteriologic changes were obtained after this period, the therapy should be discontinued. 2) The resistant bacilli to the drugs sppeared mostly within 6 months after the beginning of the chemotherapy. After this period the sensitivity to the drugs remained mostly unchanged. This aspect was observed especially in the isoniazid resistance. 3) The resistance to the drugs varied with the lesions. Because the nature of a cavity in the end of the chemotherapp was not the same as in the beginning, the appearance of the resistant bacilli were differed from the beginning. 4) The resistance to isoniazid turned often into the susceptibility in these cases. 5) The monthly resistance examinations of sputum were not only a help to the selection of the chemotherapeutic drugs, but showed that the variations of the resistance were the index of the nature of the lesions.
千葉大学の論文