抗ペニシリン性淋疾に関する実験的研究

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It is a well-known fact that there has recently been an increased number of cases of gonorrhea which do not -readily yield to penicillin therapy. This is a problem which has no small significance from the standpoint of public hygiene. However, little work has been done on this subject, and the reason why penicillin has ceased to be effective on some cases of gonorrhea is still uncertain. The present paper deals with the investigations carried out by the author on what is generally called penicillin resistant gonorrhea. The results of the investigations are summarized as follows: (1) Tests for determination of the degree of penicillin resistance of some strains of gonococci isolated from a number of prostitutes in Chiba and Kisarazu, in which the minimal concentration of penicillin required for destruction of gonococci was used as an index, showed that the highest concentration to whicn the strains tested exhibited resistance was 0.25 μ/cc. (2) In vivo tests (using rabbits) showed that repeated injections of penicillin of a concentration lower than one required for destruction of gonococci resulted in a rise in the degree of resistance of the bacteria. (3) Animal experiments (using rabbits) showed on difference in pathogenicity (ability to cause infection) between the gonococci which are resistant to the action of penicillin and those which are not. (4) Although the gonococci kept either in vitro for 8 to 9 weeks or in vivo for 5 to 6 weeks demonstrated a slight fall in the degree of penicillin resistance, it would seem that penicillin resistant gonococci do not reconvert to non-resistant state in a short period of time. (5) Animal experiments on the relation between the degree of resistance and the minimal concentration of penicillin required for the destruction of gonococci showed that 12,000 μ/kg. of penicillin brought about the destruction of the strain which had been resistant to a concentration 0.12 μ/cc. It would seem that the use of a still higher concentration is required for the destruction of the bacteria in vivo. (6) Clinical experiments showed that the cases of gonorrhea in which gonococci were resistant to concentrations lower than 0.06 μ/cc yielded to penicillin therapy, while those in which gonococci were resistant to concentrations higher than 0.12 μ/cc were beyond the power of penicillin to cure. Streptomycin has had an effect on the latter cases. (7) The results of the investigations described above would indicate that there is no doubt of the existence of penicillin resistant gonococci. The repeated use of an insufficient concentration of penicillin as a therapy of gonorrhea would only result in the rise in the degree of resistance of the bacteria to the action of penicillin; if and when the infection with these penicillin resistant gonococci spreads far and wide, penicillin would no longer be a weapon against gonorrhea. In the treatment of gonorrhea, therefore, it is essential that the patient be put on some other effective remedy, should the gonococci isolated from him be found resistant to the action of penicillin.
千葉大学の論文

著者

窪田俊文
千葉大学医学部衛生学教室

抗ペニシリン性淋疾に関する実験的研究

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